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Job Description

Nicholas Howard have an exciting 12month contract opportunity for a Senior Research Scientist to join our client, a leading Global Biopharma, working on cutting edge research to drive small molecule drug discovery using mass spectrometry.

This will be a fully lab based role, working from early stage through to preclinical projects, and will play a pivotal role in developing and delivering mass spectrometry (MS)-based assays to support the optimization of small molecule ligands as part of the drug discovery process.

Key Responsibilities:

Design, develop, and validate robust small molecule MS-based assays to support drug discovery and development programs. Optimize assay conditions to ensure high sensitivity, specificity, and reproducibility for small molecule detection and quantification Collaborate with structural biology and biophysics teams to integrate MS data with structural and biophysical insights Work closely with medicinal chemists, biologists, and other scientists to align assay development with project goals. Communicate results effectively through presentations, reports, and publications Ensure compliance with laboratory SOPs, and detailed record keeping in electronic notebook Maintain, operate and troubleshoot LCMS instrumentation for routine and novel assays

Essential:

Relevant Ph.D. or equivalent experience with proven track record of small molecule mass spec delivery Experience running and analysing quantitative small molecule mass spec assays Practical experience working with triplequad MS platforms Hands-on experience troubleshooting complex instrumentation Track record for scientific problem solving Sound understanding of data analysis principles and familiarity with data analysis software packages with particular focus on small molecule MS analysis Self-driven ability to organize resources and data, manage time and priorities. Desire to work in a fast, collaborative, and team-oriented environment. The ability to communicate clear and concise updates across a variety of audience levels, keep track of experimental records and results. Experience with data organisation and downstream reporting of MS data to other disciplines e.g. medicinal chemistry Demonstrated ability to work as part of a multidisciplinary team.

Desirable:

Experience of small molecule Affinity Selection Mass Spectrometry (AS-MS) Experience in biochemical, biophysical, bioanalytical, and/or cellular MS screening technologies Familiarity with other protein MS techniques such as Intact Mass, , HDX. Experience of working within the drug discovery industry

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